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If it is too difficult to incorporate the natural sources, then you can take a vitamin D3 supplement. Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p.451. ISBN 978-3-527-60749-5. Archived from the original on 30 December 2016 . Retrieved 29 December 2016.
Like other vitamins, vitamin D is a substance needed for health but only in tiny amounts. Unlike other vitamins, it doesn't occur naturally in food but can be made in the body. Most people know that humans use sunlight to make vitamin D, the "sunshine vitamin." But modern humans don't get much sunlight, so we end up at the vitamin counter, often confused about what to buy. Some research suggests that obesity may be associated with low vitamin D levels. It’s also believed that vitamin D could influence body weight by regulating the growth of fat cells and altering the expression of certain genes and the levels of hormones that affect hunger, such as leptin [6] Karampela I, et al. Vitamin D and Obesity: Current Evidence and Controversies. Curr Obes Rep. 2021;10(2):162-180. . Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and for many other biological effects. [1] [2] [3] In humans, the most important compounds in this group are vitamin D 3 ( cholecalciferol) and vitamin D 2 ( ergocalciferol). [2] [3] [4] You do not need a lot of sunlight for your body to synthesize vitamin D3. Experts say that getting five to ten minutes of sunlight on bare skin two to three times a week. This is not so easy in the winter months or parts of the world that don’t get a lot of sunlight.
Vitamin D3 Benefits
Whichever form of vitamin D you choose to take, make sure you get enough so you can enjoy healthy teeth and bones while protecting yourself from disease. The Role of Vitamin D3 Osteomalacia is a disease in adults that results from vitamin D deficiency. [1] Characteristics of this disease are softening of the bones, leading to bending of the spine, proximal muscle weakness, bone fragility, and increased risk for fractures. [1] Osteomalacia reduces calcium absorption and increases calcium loss from bone, which increases the risk for bone fractures. Osteomalacia is usually present when 25-hydroxyvitamin D levels are less than about 10 ng/mL. [51] Although the effects of osteomalacia are thought to contribute to chronic musculoskeletal pain, there is no persuasive evidence of lower vitamin D levels in people with chronic pain [52] or that supplementation alleviates chronic nonspecific musculoskeletal pain. [53] Osteomalacia progress to osteoporosis, a condition of reduced bone mineral density with increased bone fragility and risk of bone fractures. Osteoporosis can be a long-term effect of calcium and/or vitamin D insufficiency, the latter contributing by reducing calcium absorption. [2] Use of supplements [ edit ] Colecalciferol is a form of vitamin D. It helps your body to take in more calcium and phosphorous from the food you eat, and helps your kidneys to keep more calcium instead of peeing it out. Keeping a healthy store of vitamin D gives added protection to such diseases as cancer, multiple sclerosis, and type 1 diabetes.
Cholecalciferol was first described in 1936. [11] It is on the World Health Organization's List of Essential Medicines. [12] In 2020, it was the 60th most commonly prescribed medication in the United States, with more than 11 million prescriptions. [13] [14] Cholecalciferol is available as a generic medication and over the counter. [8] [15] [16] Medical uses [ edit ] Non-government organisations in Europe have made their own recommendations. The German Society for Nutrition recommends 20 μg. [128] The European Menopause and Andropause Society recommends postmenopausal women consume 15 μg (600 IU) until age 70, and 20 μg (800 IU) from age 71. This dose should be increased to 100 μg (4,000 IU) in some patients with very low vitamin D status or in case of co-morbid conditions. [129] Sources [ edit ]Cholecalciferol is very sensitive to UV radiation and will rapidly, but reversibly, break down to form supra-sterols, which can further irreversibly convert to ergosterol. [ citation needed] Pesticide [ edit ] Vitamin D from the diet, or from skin synthesis, is biologically inactive. It is activated by two protein enzyme hydroxylation steps, the first in the liver and the second in the kidneys. [1] [4] Because vitamin D can be synthesized in adequate amounts by most mammals if they get enough sunlight, it is not essential and therefore is technically not a vitamin. [3] Instead it can be considered a hormone, with activation of the vitamin D pro-hormone resulting in the active form, calcitriol, which then produces effects via a nuclear receptor in multiple locations. [3]
If your doctor has prescribed this medication, take as directed by your doctor. Your dosage is based on your medical condition, amount of sun exposure, diet, age, and response to treatment. Cheng Y-C, et al. The Effect of Vitamin D Supplement on Negative Emotions: A Systematic Review and Meta-Analysis. Depress Anxiety. 2020 Jun;37(6):549-564.Wang T, Bengtsson G, Kärnefelt I, Björn LO (September 2001). "Provitamins and vitamins D 2and D 3in Cladina spp. over a latitudinal gradient: possible correlation with UV levels". Journal of Photochemistry and Photobiology B: Biology. 62 (1–2): 118–22. doi: 10.1016/s1011-1344(01)00160-9. PMID 11693362. Archived from the original on 28 October 2012. To find out if you have low vitamin D levels, your doctor will give you a blood test. If your levels are severely low, they may prescribe a loading dose course of vitamin D. This is a high strength dose that is only available on prescription. Karampela I, et al. Vitamin D and Obesity: Current Evidence and Controversies. Curr Obes Rep. 2021;10(2):162-180. Holland & Barrett Vitamin D3 contributes towards the maintenance of normal bones, muscle function and the immune system.
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