Estro-Halt EU- Designed for Estrogen Support | Contains CDG, Indole-3-Carbinol & Apigenin

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Additional dose of radiation should be applied to pathological LN on imaging, preferentially using a simultaneous integrated boost (60 Gy EQD2, combined EBRT and estimated dose from IGBT). In patients with pelvic sidewall involvement, extended pelvic surgery can be considered in specialized centers. Surgery must aim for a complete tumor resection (R=0) also with the help of special techniqu es (LEER, out of box procedures), if required [IV, B]. Definitive CTRT combined with IGABT is the treatment of choice in radiotherapy naïve patients [IV, A]. The use of boost by external beam techniques to replace IGBT is not recommended [IV, D]. Balázs Madas (HU), Brita Singers Sørensen (DK), Kasper Rouschop (NL), Kerstin Borgmann (DE), Laure Marignol (IE), Martin Pruschy (CH), Navita Somaiah (UK), Nicolas Foray (FR), Paul Span (NL), Randi Syljuåsen (NO), Ross Carruthers (UK) Resveratrol Reduces oxidative stress and inflammation to improve general health. Plus, can help increase insulin sensitivity to minimise blood sugar spikes and improve focus.

Radical surgery or definitive CTRT according to the disease stage as recommended outside pregnancy, if the woman decides not to preserve the pregnancy. Pregnancy termination is recommended before any treatment after the first trimester, and fetus evacuation before CTRT, if possible. Radical trachelectomy (type B) should be performed in patients with cervical cancer T1b1, LVSI-positive. In patients without deep stromal involvement and with a high probability of adequate endocervical tumor free margins, simple trachelectomy can be considered [III, B]. Intraoperative assessment of sentinel nodes is a reliable procedure but may miss micrometastases and isolated tumor cells. Intraoperative assessment should be performed on a grossly suspicious sentinel node and may be performed on a “non-suspicious” SLN because the confirmation of tumor involvement will result in abandoning a hysterectomy or trachelectomy. For intraoperative evaluation, the SLN should be sent to the pathology department in a container without liquid fixative. Intraoperative analysis requires gross dissection of the resected adipose tissue by the pathologist and selection of LN. It is important to leave some peri-nodal tissue allowing proper diagnosis of extra-nodal tumor spread. For a LN with obvious gross tumor, a single section is adequate for frozen section. Pelvic magnetic resonance imaging (MRI) is mandatory for initial assessment of pelvic tumor extent and to guide treatment options (optional for T1a tumor with free margins after conization). Endovaginal/transrectal ultrasonography is an option if performed by a properly trained sonographer [II, A]. Management of disease found after SH should be based on expert pathology review and discussed in a multidisciplinary tumor board. In general, management of occult disease follows the principles of the standard management, and is based on pathologic findings, and clinical staging. Treatment strategy should aim to avoid combining further surgery and radiotherapy because of the high morbidity after combined treatment [III, B].Fertility sparing therapy for patients with tumors greater than 2 cm is significantly associated with a higher risk of recurrence and should not be considered as a standard treatment. The risk of recurrence must be comprehensively discussed with the patient. NACT followed by radical vaginal trachelectomy and abdominal radical trachelectomy or cone has been described for fertility sparing treatment in patients with tumors >2 cm. PLN staging should be performed before starting NACT to confirm tumor-free LN. The optimal number of chemotherapy cycles, chemotherapy regimen as well as extent of cervical resection following NACT, are still a matter of debate [IV, B]. LN assessment should be performed as the first step of surgical management [IV, A]. Minimally invasive surgery is an acceptable approach for LN staging [IV, B]. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. SLN biopsy (without additional PLND) can be considered in LVSI-negative patients but should be performed in LVSI-positive patients [IV, B].

ESTRO’s mission is to promote innovation, research, and dissemination of science through its congresses, special meetings, educational courses and publications. Job objective Patients with a persistent tumor 3–6 months after definitive CTRT and BT and without evidence of regional or metastatic disease should be referred to specialized centers for evaluating the necessity and the possibility of performing salvage surgery (see management of recurrent disease and follow-up sections) [IV, B]. For individuals who are pregnant, nursing, or managing known medical conditions, it is essential to seek guidance from a healthcare professional before use. Those with known allergies should exercise additional caution and conduct thorough research on the herbs' potential associations with allergies. Founded in 1980, ESTRO, the European Society for Radiotherapy & Oncology (ESTRO), is a non-profit and scientific organisation that aims at reinforcing radiation oncology as a core partner in multidisciplinary cancer care and at guaranteeing accessible and high-value radiation therapy for all cancer patients who need it. Localized para-aortic, mediastinal, and/or peri-clavicular recurrences out of previously irradiated fields may be treated by radical EBRT with or without chemotherapy [IV, C].Ben Heijmen (NL), Catharine Clark (UK), Charlotte Robert (FR), Christian Richter (DE), Coen Hurkmans (NL), Daniela Thorwarth (DE), Dietmar Georg (AT), Edmond Sterpin (BE), Eduard Gershkevitsh (EE), Faisal Mahmood (DK), Georgina Fröhlich (HU), Iuliana Toma-Dasu (SE), Kathrine Røe Redalen (NO), Livia Marrazzo (IT), Núria Jornet (ES), Ye Zhang (CH)

Quality of life and side effects should be regularly assessed at least by the physicians/clinical care nurses and if possible by patients (using patient related outcomes). Patient self-reporting of side effects should be encouraged during and after treatment with the same frequency as medical visits [IV, B]. Para-aortic LN dissection (PALND), at least up to inferior mesenteric artery, may be considered in locally advanced cervical cancer with negative para-aortic LN on imaging for staging purposes [IV, C]. The therapeutic effect of nodal resection/debulking is unclear and should, if possible, be followed by radiotherapy [IV, C]. to 5 years of relevant and proven experience in marketing and communications creating content to support organisational goals, preferably in a non-profit association of a scientific nature. The same imaging method used at the start of treatment should be used to assess tumor response [V, B].

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Any pregnancy following fertility sparing therapy should be considered as a high-risk pregnancy. Following simple or radical trachelectomy with placement of a permanent cerclage, delivery can only be performed by cesarean section [IV, B].

Calcium D-glucarate Calcium D-glucarate helps support detoxification by helping the body to effectively remove excess estrogen. An exhibition featuring equipment and medical publishers will be held in the Exhibition area. The exhibition will open on Friday evening with the Networking evening and will remain open to the visitors from Saturday to Monday. Entrance is free for all registered participants. Companies and publishers who would like to participate in the exhibition may obtain more detailed information from the ESTRO Office.Previous pertinent histological exams of the cervical lesion/cancer, even if diagnosed in another institution, should be revised and integrated in the final report (eg, cone biopsy and hysterectomy specimen) Jointly with the IT department, ensure the effective operation and maintenance of the platform, aiming for optimal functionality. The patient should be discussed in a multidisciplinary team and should be counseled for the advantages and disadvantages of both treatment options (surgery vs radiotherapy) in relation to the individual presence of prognostic factors [IV, A]. Work with consultants and suppliers to create visually engaging materials, including infographics, printed materials, and videos in line with ESTRO branding. For patients with free surgical margins and in the absence of residual tumor on imaging (including non-suspicious LN), (chemo)radiotherapy is recommended as a treatment that avoids further surgical management [IV, B].