Berberine Extract 1000mg 30 Capsules Vegan Organic Capsules 100% Natural by Vytox. 1 Month Supply

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Peng, L., et al. (2015). Antibacterial activity and mechanism of berberine against Streptococcus agalactiae. Berberine could be an effective antimicrobial agent. A 2022 study found that berberine helped inhibit the growth of Staphylococcus aureus.

Preparation and Evaluation of Antidiabetic Agents of - PubMed Preparation and Evaluation of Antidiabetic Agents of - PubMed

Many factors that can be measured in your blood are associated with an increased risk of heart disease.Berberine can enrich the population of butyrate-producing bacteria in the GM ( Wang etal., 2017b). Butyrate-induced upregulation of GLP-1 and PYY may be important in preventing or treating obesity and insulin resistance ( Vidrine etal., 2014). Treatments with butyrate or increasing butyrate productions have been shown to prevent or attenuate obesity and insulin resistance ( Li M. etal., 2016; Li X. et al., 2016; Goldsmith etal., 2017; Zhang etal., 2017). Butyrate has also been shown to increase B-adrenergic receptor profiles in adipocytes, which occurs via HDACi activity, a similar mechanism for upregulating fatty acid oxidation may occur in white adipose tissue ( McNabney and Henagan, 2017). The HDACi activity of butyrate has also been associated with its ability to prevent adipose tissue inflammation, a contributing factor to insulin resistance during obesity ( Ding etal., 2000; Wang etal., 2015). N-(1-carbamoyl-2-phenyl-ethyl) butyramide (FBA), a synthetic more palatable derivative of butyrate, in mice fed the HFD reduces hepatic fat accumulation and decreases metabolic/mitochondrial efficiency, counteracting obesity, IR, and inflammation ( Mollica etal., 2017). Elevation of SCFA availability by increasing dietary fiber intake or diet supplementation with butyrate may prevent the development of metabolic disarrangements and the insulin resistance associated with obesity ( Galisteo etal., 2008; Nilsson etal., 2010). The Effects of Berberine on Hyperlipidemia Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide ( Huang et al., 2021). Studies indicate that the abnormal proliferation of vascular smooth muscle cells (VSMCs) is involved in the pathogenesis of CVD ( Xiang et al., 2020; Zhang et al., 2021a). It has also been demonstrated that berberine (10, 30 and 100μmol/L) could inhibit angiotensin IV-induced proliferation in cultured VSMCs by targeting the peroxisome proliferator-activated receptor α (PPAR-α)–nitric oxide (NO) signaling pathway ( Qiu et al., 2017). Myocardial Ischemia Some research suggests that berberine works similarly to the drug metformin, which doctors often prescribe to treat type 2 diabetes. In fact, berberine may have the ability to change the bacteria in the gut, which could help treat both obesity and diabetes. Polycystic ovary syndrome

Berberine: Benefits, supplements, side effects, dosage, and more

Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China Polycystic ovary syndrome (PCOS) occurs when a female has high levels of certain male hormones. The syndrome is a hormonal and metabolic imbalance that can lead to infertility and other health issues. Berberine activated a population with immune suppressive function, defined as granulocytic‐ myeloid‐derived suppressor cell (G‐MDSC)‐like population, in the liver of mice with alleviating ALD. Berberine remarkably enhanced the increase of G‐MDSC‐like cells in blood and liver and decreased cytotoxic T cells correspondingly. Moreover, berberine changed the overall gut microbial community, primarily increased the abundance of A. muciniphila. Of note, depletion of gut microbiota abolished the inducing effect of berberine on G‐MDSC‐like population, and attenuated its hepatoprotective effect against alcohol in mice, suggesting intestinal flora might be involved in mediating the expansion of this protective population ( Li S. etal., 2020). Patients with ALD have been shown to possess an increased abundance of endotoxin-producing Enterobacteriaceae, and a reduced abundance of SCFAs-producing bacteria, such as Lachnospiraceae and Ruminococcaceae. In a previous study, Grander etal. (2018) showed that A. muciniphila, a commensal type of bacteria, was associated with intestinal mucous layer in alcoholic hepatitis. These authors showed that clinical stool samples from patients with alcoholic hepatitis had the lowest relative abundance of A.muciniphila. Further experiments, using a mouse(C57BL/6J) model of ALD, reported improvements in alcohol-associated hepatic disease and intestinal barrier function following the administration of A. muciniphila ( Grander etal., 2018). Other studies have shown that berberine can regulate SCFA-producing bacteria ( Wang etal., 2017). Human and animal experiments in ALD and cirrhosis have further demonstrated that probiotics, including Lactobacillaceae spp. can improve the outcomes of these diseases ( Han etal., 2015). The team behind another study observed that berberine may activate brown adipose tissue. This tissue helps the body turn food into body heat, and increased activation may help treat obesity and metabolic syndrome.However, it may be a good choice for people who don’t want to take three split-up doses throughout the day, as this supplement recommends only taking one serving per day. However, sometimes our couriers encounter delays in which case delivery can take up to 4 working days. Lee, Y. S., et al. (2006). Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Also, a double-blind study found that individuals with metabolic syndrome who took 200 mg of barberry three times a day experienced decreases in their body mass index readings. Zhang etal. also reported that berberine modulated the GM, enriched the population of SCFA-producing bacteria, and regulated microbial diversity, thus enhancing intestinal integrity ( Zhang etal., 2015). These authors also revealed that Phascolarctobacterium, Anaerotruncus, and Oscillibacter, may be solely responsible for the beneficial effects of berberine on intestinal permeability. Berberine increased the expression of ZO-1 mRNA by inhibiting the abundance of Oscillibacter, thus antagonizing obesity.

Berberine and Diabetes: Safety, Dosage, and Review - Healthline Berberine and Diabetes: Safety, Dosage, and Review - Healthline

Berberine has also been shown to significantly reduce inflammation, fibrosis, and the levels of lipid peroxides in the liver ( Zhang etal., 2016). The lipid-lowering effect of berberine occurs via a series of continuous events, including bile salt hydrolase (BSH) inhibition, significant increases in the levels of tauro-conjugated bile acids (especially TCA), and the activation of the FXR signaling pathway. These events reduce the expression levels of CD36 in the liver which then leads to a reduction in the hepatic uptake of long-chain fatty acids and the modulation of lipid metabolism in the liver ( Sun etal., 2017).

Diabetes, high blood sugar levels, and obesity are also major risk factors for heart disease, and this supplement seems to help improve all of these conditions ( 7). Lichao Zhang 1,2,3† Xiaoying Wu 1,2,4† Ruibing Yang 5 Fang Chen 6 Yao Liao 1,2,3 Zifeng Zhu 1,2,3 Zhongdao Wu 1,2,3 Xi Sun 1,2,3* Lifu Wang 1,2,3* Habtemariam, S. (2020). Berberine pharmacology and the gut microbiota: A hidden therapeutic link [Abstract].