MAGNE B6 MAX - 50 Capsules - is a Dietary Supplement containing in its Composition Magnesium and Vitamin B6, for People Suffering Weakness, Fatigue, Twitching eyelids and Muscle spasms

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a b c d Ghatge MS, Al Mughram M, Omar AM, Safo MK (April 2021). "Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies". Biochimie. 183: 18–29. doi: 10.1016/j.biochi.2020.12.025. PMID 33421502. S2CID 231437416.

PLP is a required coenzyme of glycogen phosphorylase, the enzyme necessary for glycogenolysis. Glycogen serves as a carbohydrate storage molecule, primarily found in muscle, liver and brain. Its breakdown frees up glucose for energy. [6] PLP also catalyzes transamination reactions that are essential for providing amino acids as a substrate for gluconeogenesis, the biosynthesis of glucose. [15] Lipid metabolism [ edit ]Serine racemase which synthesizes the neuromodulator D-serine from its enantiomer is a PLP-dependent enzyme. Vitamin B6 may play a role in preventing eye diseases, especially a type of vision loss that affects older adults called age-related macular degeneration (AMD).

Studies have linked low levels of vitamin B6 with anemia, especially in pregnant women and women of childbearing age ( 20, 21). Less severe cases present with metabolic disease associated with insufficient activity of the coenzyme pyridoxal 5’ phosphate (PLP). [1] The most prominent of the lesions is due to impaired tryptophan– niacin conversion. This can be detected based on urinary excretion of xanthurenic acid after an oral tryptophan load. Vitamin B 6 deficiency can also result in impaired transsulfuration of methionine to cysteine. The PLP-dependent transaminases and glycogen phosphorylase provide the vitamin with its role in gluconeogenesis, so deprivation of vitamin B 6 results in impaired glucose tolerance. [1] [15] Diagnosis [ edit ] György P (1934). "Vitamin B2 and the Pellagra-like Dermatitis in Rats". Nature. 133 (3361): 498–9. Bibcode: 1934Natur.133..498G. doi: 10.1038/133498a0. S2CID 4118476. Daily Value Reference of the Dietary Supplement Label Database (DSLD)". Dietary Supplement Label Database (DSLD). Archived from the original on 7 April 2020 . Retrieved 16 May 2020.These amounts of B6 are significantly higher than the RDA and sometimes combined with other B vitamins. It’s difficult to assess if increasing intake of B6 from dietary sources has the same benefits for certain conditions that supplements may provide. PLP is a coenzyme needed for the proper function of the enzymes cystathionine synthase and cystathionase. These enzymes catalyze reactions in the catabolism of methionine. Part of this pathway (the reaction catalyzed by cystathionase) also produces cysteine. The European Food Safety Authority (EFSA) refers to the collective set of information as Dietary Reference Values, with Population Reference Intake (PRI) instead of RDA. For women and men ages 15 and older the PRI is set at 1.6 and 1.7mg/day, respectively; for pregnancy 1.8mg/day, for lactation 1.7mg/day. For children ages 1–14 years the PRIs increase with age from 0.6 to 1.4mg/day. [22] The EFSA also reviewed the safety question and set its UL at 25mg/day. [23] [24] a b Schorgg P, Bärnighausen T, Rohrmann S, Cassidy A, Karavasiloglou N, Kühn T (May 2021). "Vitamin B6 Status among Vegetarians: Findings from a Population-Based Survey". Nutrients. 13 (5): 1627. doi: 10.3390/nu13051627. PMC 8150266. PMID 34066199. A deficiency of vitamin B 6 alone is relatively uncommon and often occurs in association with other vitamins of the B complex. Evidence exists for decreased levels of vitamin B 6 in women with type 1 diabetes and in patients with systemic inflammation, liver disease, rheumatoid arthritis, and those infected with HIV. [42] [43] Use of oral contraceptives and treatment with certain anticonvulsants, isoniazid, cycloserine, penicillamine, and hydrocortisone negatively impact vitamin B 6 status. [1] [44] [45] Hemodialysis reduces vitamin B 6 plasma levels. [46] Genetic defects [ edit ]

a b "Tolerable Upper Intake Levels For Vitamins And Minerals" (PDF). European Food Safety Authority. 2006. Archived (PDF) from the original on 19 September 2017.Some drugs when used together with Magne B6 can affect the therapeutic effect of the drug or vice versa. In infants, a deficiency in vitamin B 6 can lead to irritability, abnormally acute hearing, and convulsive seizures. [1] a b c d e f g h i j k l m Institute of Medicine (1998). "Vitamin B 6". Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press. pp.150–195. doi: 10.17226/6015. ISBN 978-0-309-06554-2. LCCN 00028380. OCLC 475527045. PMID 23193625. PLP is involved in many aspects of macronutrient metabolism, neurotransmitter synthesis, histamine synthesis, hemoglobin synthesis and function, and gene expression. PLP generally serves as a coenzyme (cofactor) for many reactions including decarboxylation, transamination, racemization, elimination, replacement, and beta-group interconversion. [2] [3] [15] Amino acid metabolism [ edit ] Overview of Dietary Reference Intakes for Japanese" (PDF). Ministry of Health, Labour and Welfare (Japan). 2015 . Retrieved 19 August 2021.